DNAIQ is committed to using its resources in support of increased understanding of SARS-CoV-2 host genetic susceptibility. A curated list of recent research and links on the virus follows. Please note that some articles are sourced from preprint servers and have yet to be peer-reviewed.

Above:  electron microscope image of a coronavirus virion ‘crowned’ by spike glycoproteins on its surface. The virus uses these glycoproteins to anchor to angiotensin-converting enzyme 2 (ACE2) receptors on human cells. If the transmembrane protease encoded by TMPRS22 is near the site of attachment, the viral membrane and host cell membrane fuse and the virus injects its RNA into the host cell.

AI-driven tools that mine coronavirus literature

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vaccine development

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Clinical Trials Link
mRNA vaccines introduce an mRNA molecule that encodes an aspect of the virus that becomes expressed from cells as an antigenic determinant – in this case the spike protein of SARS-Cov-2.  So far this vaccine has demonstrated the production of higher titres of neutralising antibodies compared to patients recovered from COVID19, however there were significant (but non-lethal) side effects in over 50% of participants. 

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

immunity

Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection
Antibody levels in confirmed COVID-19 patients decline dramatically within two months. In some cases antibody levels following recovery are undetectable. 

Human leukocyte antigen susceptibility map for SARS-CoV-2

Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
SARS-Cov-2 reactive T cells detected in 40-60% of unexposed individuals due to exposure from common cold coronaviruses

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

serology test performance

Evaluation of nine commercial SARS-CoV-2 immunoassays

Test performance evaluation of SARS-CoV-2 serological assays

Post-market validation of three serological assays for COVID-19 (Australia)

use of dried blood spots in serology

Enzyme immunoassay for SARS-CoV-2 antibodies in dried blood spot samples: A minimally-invasive approach to facilitate community- and population-based screening 

infection sites

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Salivary Glands: Potential Reservoirs for COVID-19 Asymptomatic Infection
Salivary glands express high levels of ACE2 receptor and virus is detected in saliva before it is detectable in throat and lungs

infection duration

Clearance and persistence of SARS‐CoV‐2 RNA in patients with COVID‐19
Evidence of patients with mild symptoms continuing to test  positive via PCR for 40 days or more; based on antibody presence, suggests a weaker immune response results in attenuated disease severity 

platelets

Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with coronavirus disease‐19
Elevated platelet counts associated with greater disease severity

Platelet Gene Expression and Function in COVID-19 Patients
Platelets do not express the ACE2 receptor but SARS-CoV-2 mRNA is present in  platelets of infected patients (suggesting an additional yet unidentified viral receptor); platelets become hyperactive and may contribute to COVID-19 pathology such as the presence of micro clots 


treatment

Evidence Based Management Guideline for the COVID-19 Pandemic – Review article

Pharmacologic Treatments – Review Apr 2020

Acute Treatment Guidelines

Preliminary Convalescent Plasma Results

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19

prophylaxis & treatment hypotheses

Existing bitter medicines for fighting 2019-nCoV-associated infectious diseases

Therapeutic Potential for Tetracyclines in the Treatment of COVID-19

Targeting SARS-CoV-2: A Systematic Drug Repurposing Approach to Identify Promising Inhibitors Against 3C-like Proteinase and 2′-O-RiboseMethyltransferase

Risk Factors:

Neanderthal genes

The major genetic risk factor for severe COVID-19 is inherited from Neandertals
the genetic region showing the strongest signal for risk of severe COVID-19 is a 50 kb segment of the genome that is inherited from Neaderthals; for 23andme/Ancestry users the SNP that tags this site is rs10490770 (G)

male sex

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

low testosterone in males

Testosterone, a key hormone in the context of COVID-19 pandemic

The majority of male patients with COVID-19 present low testosterone levels on admission to Intensive Care in Hamburg, Germany: a retrospective cohort study.

air pollution

Assessing nitrogen dioxide (NO2) levels as a contributing factor to coronavirus (COVID-19) fatality

SARS-Cov-2 RNA Found on Particulate Matter of Bergamo in Northern Italy: First Preliminary Evidence

inflammatory response

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

Association of inflammatory markers with the severity of COVID-19

Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis

Prognostic value of C-reactive protein in patients with COVID-19

Metabolic disturbances and inflammatory dysfunction predict severity of coronavirus disease 2019 (COVID-19): a retrospective study

Correlation Analysis Between Disease Severity and Inflammation-related Parameters in Patients with COVID-19 Pneumonia

tobacco smoking 

Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2

diabetes

Comorbid Diabetes Mellitus was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

Effects of hypertension, diabetes and coronary heart disease on COVID-19 diseases severity: a systematic review and meta-analysis

ageing

Biomarkers of biological age as predictors of COVID-19 disease severity

COVID-19 is an emergent disease of aging

Why Does COVID-19 Disproportionately Affect the Elderly?

inherited arrhythmia

SARS-CoV-2, COVID-19 and inherited arrhythmia syndromes

obesity

High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation.

Prolonged viral shedding in obese subjects

blood type  

Testing the association between blood type and COVID-19 infection, intubation, and death

vitamin D

Vitamin D Insufficiency is Prevalent in Severe COVID-19

genetic susceptibility to covid19 infection

Initial Review and Analysis of COVID-19 Host Genetics and Associated Phenotypes

IFITM3: How genetics influence influenza infection demographically

ACE2 variants underlie interindividual variability and susceptibility to COVID-19 in Italian population

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

Host susceptibility to severe influenza A virus infection

Structural variations in human ACE2 may influence its binding with SARS‐CoV‐2 spike protein

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

ACE2 and TMPRS22 gene expression

EBI gene expression data

proteins that interact with virus

Human Proteome Atlas